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The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in adults with a body mass index (BMI) of more than 27, provided they also experience weight-related health concerns such as Tupe2 diabestes, high cholesterol and/or hypertension (high blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so when an aid to smoking cessation treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle that includes a reduced-calorie eating and working out, Contrave provides another treatment option for chronic weight loss for people who are obese or are overweight and still have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercise. Results from a clinical study that enrolled patients without diabetes established that patients had an average weight loss of 4.1% rather than participants who have been given placebos) after a 12- month period, while another study involving patients with diabetes type 2 symptoms had the average weight loss of 2% over treatment with placebo at one year.

Using two separate drugs to lose weight can be very effective you can find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the individuals who go through it one should err on the side of caution and allow the FDA do its job and demand some study be done so the public understands the side effects and hazards of the medications before we bring them. Keep in mind that drug companies are in business to generate money and that they would say almost anything to keep people on their own medications.

Researchers discovered that participants taking this drug for a year, lost excess weight within a month and have kept the weight off through the 56 weeks of the study. Contrave is a combination with the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs that are made up of several active ingredient, that might make them far better and safer.

Combo-pilling will be the newest fad or in addition to this the newest into the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills is now popular may be the fact that by right now there aren't any long term prescription diet pills that have been licensed by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be licensed by the FDA.

Seizures really are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug can also raise blood pressure levels and heartrate, and mustn't be used in people who have a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure levels and heart rate and must not used in patients with uncontrolled high blood pressure, in addition to by a person with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients with a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients to the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.

Suboxone contains two drugs; buprenorphine and naloxone. The naloxone is irrelevant if your addict uses the medication properly, but if your tablet is dissolved in water and injected the naloxone may cause instant withdrawal. When suboxone can be used correctly, the naloxone is destroyed in the liver shortly after uptake from the intestines and it has no therapeutic effect. Buprenorphine could be the active substance; it's absorbed under the tongue (and through the entire mouth) but destroyed from the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I manipulate this formulation if the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have treated addicts who may have had gastric bypass, the location where the first area of the intestine is bypassed along with the stomach contents empty right into a more distal section of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the method with normal anatomy where the drug is taken up with the duodenum and transferred straight to the liver by the portal vein, where it really is quickly and completely destroyed. After gastric bypass naloxone can be taken on by portions of the intestine which are not served through the portal system, causing blood numbers of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.

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